UNIT-03 · ONLINE · DISCOVERY

Q EXACTIVE PLUS
ORBITRAP

HIGH-RESOLUTION ACCURATE-MASS · NON-TARGET SCREENING

Non-target discovery — exact-mass identification of any unknown, in any matrix.

24–48HRTURNAROUND
~45MINCYCLE TIME
~30SAMPLES / DAY
280KFWHM RES
01

WHAT IT READS

EXACT MASS · ISOTOPE PATTERN
???

UNKNOWN IMPURITIES

Exact-mass formula assignment — any matrix

<3 PPM MASS
O&G

OIL & GAS PROFILE

Crude · condensate · process streams — full impurity map

FULL PROFILE
DEG

DEGRADATION PRODUCTS

Oxidation · hydrolysis · photolysis — stability lots

NTA SCREEN
E&L

CONTAMINANTS

Extractables & leachables — packaging contact

TRACE ID
ISO

ISOMERS

Structural elucidation — HCD-fragment confirmed

MS/MS CONFIRM
ADD

ADDITIVE BREAKDOWN

Polymer · lubricant · antioxidant decay products

FINGERPRINT
02

THE PROCESS

IONIZE → TRAP → IDENTIFY
STEP 01

UHPLC FRONT END

Vanquish UHPLC resolves the mixture by retention time; NanoAcquity handles low-flow trace work.

STEP 02

HESI-II IONIZATION

Heated electrospray nebulizes the eluent in N₂ — soft, intact ions ready for the trap.

STEP 03

ORBITRAP DETECTION

The C-trap injects ion packets into the Orbitrap; image-current decay yields 280,000 FWHM resolution across m/z 50–6,000.

STEP 04

HCD FRAGMENTATION

Higher-energy collisional dissociation maps daughter ions — the compound's structural fingerprint.

STEP 05

FORMULA ASSIGNMENT

Exact mass + isotope pattern + fragment match proposes the molecular formula to four decimal places.

<3 PPM MASS ERROR SUB-PPM LOCK-MASS ISOTOPE-PATTERN CONFIRM 4-DECIMAL EXACT MASS
03

THE UNIT

HYBRID TRAP · HCD CELL
Thermo LTQ Orbitrap XL hybrid mass spectrometer with Velos Pro ion trap on a lab bench
ORBITRAP — REPRESENTATIVE CLASS UNIT

PHOTO: THERMO LTQ ORBITRAP XL — REPRESENTATIVE OF THE Q EXACTIVE CLASS.

RESULTS IN 24 HOURS OR LESS

EXACT MASS → MOLECULAR FORMULA

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